Ivan PavlovIvan Pavlov was born into an impoverished family in the rural village of Ryazan, Russia. He won a government scholarship to the University of St. Petersburg and studied medicine at the Imperial Medical Academy, receiving his degree in 1883. In 1890, Pavlov was appointed to a professorship at the St. Petersburg Military Academy, and a few years later he joined the faculty of the University of St. Petersburg. He organized the Institute of Experimental Medicine in 1895, which was to be his research laboratory for the next 40 years.
In the 1890s, Pavlov investigated the workings of the digestive system, focusing on digestive secretions, using special surgically created openings in the digestive tracts of dogs, a project strongly influenced by the work of an earlier physiologist, Ivan Sechenov (1829– 1905). As a result of this research, Pavlov was awarded the Nobel Prize for Physiology and Medicine in 1904. During his investigations in this area, Pavlov observed that normal, healthy dogs salivate upon seeing their keeper, apparently in anticipation of being fed. This observation led Pavlov, through a systematic series of experiments, to formulate the principles of the conditioned response, which he believed could be applied to humans as well as to animals. According to Pavlov's system, an unconditioned stimulus, such as offering food to a dog, produces a response, or unconditioned reflex, (or an unconditioned response), that requires no training (salivation). In contrast, a normally neutral act, such as ringing a bell, becomes a conditioned stimulus when associated with the offering of food and eventually will produce salivation on its own, but as a conditioned reflex (or conditioned response). According to Pavlov, the conditioned reflex is a physiological phenomenon caused by the creation of new reflexive pathways created in the cortex of the brain by the conditioning process. In further studies of the cortex, Pavlov posited the presence of two important processes that accompany conditioning: excitation, which leads to the acquisition of conditioned responses, and inhibition, which suppresses them. He eventually came to believe that cortical inhibition is an important factor in the sleep process...